When is Esketamine typically prescribed?

Esketamine is often prescribed when patients have not responded to at least two different types of antidepressant therapies. This approach is part of a strategy to manage treatment-resistant depression, where traditional medications have not been effective. This option aligns with the current guidelines and clinical recommendations that suggest that Esketamine is typically considered for individuals who have already tried and not adequately responded to conventional antidepressants.

The rationale behind this practice is to ensure that Esketamine is used as an additional therapy for those who may benefit from a different mechanism of action. This method not only helps to avoid unnecessary or early interventions but also prioritizes patient safety and ensures comprehensive treatment planning.